A tube holder for a tube-filling machine has a cup-shaped housing, which has an upwardly opening tube mount, into which a tube can be inserted with an axial end area thereof. A clamping device, by which a clamping force can be applied to the tube, is arranged in the area of the tube wall of the tube mount. Provisions are made for the clamping device to have at least one inflatable clamping element with an inner chamber, into which a pressurized fluid can be filled through a feed line. The clamping element can be adjusted between a clamping position, in which a clamping force is applied to the tube, and a releasing position, in which no clamping force is preferably applied to the tube.