- 专利标题： Tumescent infiltration drug delivery of high subcutaneous drug concentrations with prolonged local and systemic effects and minimal local or systemic toxicity
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申请号： US17675506申请日： 2022-02-18
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公开(公告)号： US11723859B2公开(公告)日： 2023-08-15
- 发明人: Jeffrey Alan Klein , Paytra Alan Klein
- 申请人： HK Pharma
- 申请人地址： US CA San Clemente
- 专利权人： HK Pharma
- 当前专利权人： HK Pharma
- 当前专利权人地址： US CA San Clemente
- 代理机构： Knobbe Martens Olson & Bear LLP
- 主分类号： A61K31/67
- IPC分类号： A61K31/67 ; A61K9/00 ; A61K31/522 ; A61K31/137 ; A61K31/52 ; A61K9/08 ; A61K31/56 ; A61K45/06 ; A61K31/546 ; A61K31/4164 ; A61K47/02 ; A61K31/167
摘要：
A tumescent composition comprising a chemotherapy agent in a tumescent solution, wherein a tumescent concentration of the chemotherapy agent is simultaneously below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; and the tumescent solution comprises a vasoconstrictor; a pharmaceutically acceptable carrier; and optionally a local anesthetic.
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