公开(公告)号：US10786483B2

公开(公告)日：2020-09-29

申请号：US15449488

申请日：2017-03-03

申请人： HK Pharma

发明人： Jeffrey Alan Klein ,  Paytra Alan Klein ,  Bram Alan Klein

IPC分类号： A61K31/46 ,  A61K9/00 ,  A61K47/02 ,  A61K31/404 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K45/06 ,  A61M5/145 ,  A61M5/178

摘要： A tumescent contravenom solution including: (a) a vasoconstrictor, (b) a physiological crystalloid solution, and (c) optionally a contravenom agent that neutralizes tissue toxic enzymes present in a venom and/or a drug that impairs or paralyzes lymphatic smooth muscle function and impairs lymphatic transport of venom. Also described are methods of treating an envenomation in a subject, and a kit for performing the method of treating an envenomation.

公开(公告)号：US11213481B2

公开(公告)日：2022-01-04

申请号：US16443767

申请日：2019-06-17

申请人： HK PHARMA

发明人： Jeffrey Alan Klein

IPC分类号： A61K9/00 ,  A61K45/06 ,  A61K31/137 ,  A61K31/167 ,  A61M5/14 ,  A61K31/546 ,  A61M25/00

摘要： A method of subcutaneous delivery of a drug or a therapeutic agent to a subject to treat a localized condition, the method including obtaining a liquid composition including the drug or the therapeutic agent dissolved in a tumescent solution, wherein the tumescent solution includes the drug or the therapeutic agent a vasoconstrictor; and a pharmaceutically acceptable carrier; and delivering a mass of the liquid composition subcutaneously to a localized tissue in the subject, wherein the drug or the therapeutic agent treats the localized condition in the localized tissue, wherein a concentration of the drug or the therapeutic agent subcutaneously delivered exceeds a concentration of the drug or the therapeutic agent that can be safely achieved by intravenous delivery, and wherein an amount of the drug or the therapeutic agent located at an outer boundary of the mass of fluid and available for absorption is less than an amount of the drug or the therapeutic agent located within a central portion of the mass of fluid and virtually isolated from the systemic circulation by virtue of capillary vasoconstriction.

公开(公告)号：US20190298648A1

公开(公告)日：2019-10-03

申请号：US16443767

申请日：2019-06-17

申请人： HK PHARMA

发明人： Jeffrey Alan Klein

IPC分类号： A61K9/00 ,  A61K31/546 ,  A61K31/167 ,  A61M5/14 ,  A61K45/06 ,  A61K31/137

摘要： A method of subcutaneous delivery of a drug or a therapeutic agent to a subject to treat a localized condition, the method including obtaining a liquid composition including the drug or the therapeutic agent dissolved in a tumescent solution, wherein the tumescent solution includes the drug or the therapeutic agent a vasoconstrictor; and a pharmaceutically acceptable carrier; and delivering a mass of the liquid composition subcutaneously to a localized tissue in the subject, wherein the drug or the therapeutic agent treats the localized condition in the localized tissue, wherein a concentration of the drug or the therapeutic agent subcutaneously delivered exceeds a concentration of the drug or the therapeutic agent that can be safely achieved by intravenous delivery, and wherein an amount of the drug or the therapeutic agent located at an outer boundary of the mass of fluid and available for absorption is less than an amount of the drug or the therapeutic agent located within a central portion of the mass of fluid and virtually isolated from the systemic circulation by virtue of capillary vasoconstriction.

公开(公告)号：US20240148776A1

公开(公告)日：2024-05-09

申请号：US18501539

申请日：2023-11-03

申请人： HK Pharma

发明人： Jeffrey Alan Klein ,  Paytra Alan Klein ,  Bram Alan Klein

IPC分类号： A61K31/714 ,  A61K9/00 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4025 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61P23/02 ,  A61P25/02 ,  A61P31/22

CPC分类号： A61K31/714 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4025 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61P23/02 ,  A61P25/02 ,  A61P31/22

摘要： A tumescent solution including: a vasoconstrictor; a B vitamin and a pharmaceutically acceptable carrier. In some examples, the tumescent solution further includes a drug or therapeutic agent dissolved in the tumescent solution. Some examples relate to a method of subcutaneous delivery of a drug or therapeutic agent to a subject including subcutaneously administering to said subject a tumescent solution as disclosed herein. In some examples, infiltration of the tumescent solution achieves both prolonged local drug or therapeutic agent concentration within a tumescent subcutaneous tissue as well as a prolonged slow constant systemic absorption of drugs from the tumescent tissue into a systemic circulation. In some examples, the tumescent solution reduces neuropathic pain or the risk of developing neuropathic pain, treats a localized condition or reduces persistent postsurgical pain (PPP) in a subject.

公开(公告)号：US11241412B2

公开(公告)日：2022-02-08

申请号：US16264440

申请日：2019-01-31

申请人： HK Pharma

发明人： Jeffrey Alan Klein ,  Paytra Alan Klein

IPC分类号： A61K31/352 ,  A61K31/137 ,  A61K31/522 ,  A61K9/107 ,  A61K9/00 ,  A61P23/02 ,  A61P31/20

摘要： A tumescent composition including a cannabinoid dissolved in a tumescent solution, wherein the tumescent solution includes a local anesthetic; a vasoconstrictor; and a pharmaceutically acceptable carrier, wherein a tumescent concentration of the cannabinoid is 1-2000 μg/kg and is simultaneously: below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery. Also disclosed are methods of subcutaneous delivery of a cannabinoid to a subject including administering to the subject the tumescent composition.

公开(公告)号：US11723859B2

公开(公告)日：2023-08-15

申请号：US17675506

申请日：2022-02-18

申请人： HK Pharma

发明人： Jeffrey Alan Klein ,  Paytra Alan Klein

IPC分类号： A61K31/67 ,  A61K9/00 ,  A61K31/522 ,  A61K31/137 ,  A61K31/52 ,  A61K9/08 ,  A61K31/56 ,  A61K45/06 ,  A61K31/546 ,  A61K31/4164 ,  A61K47/02 ,  A61K31/167

CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4164 ,  A61K31/52 ,  A61K31/522 ,  A61K31/546 ,  A61K45/06 ,  A61K47/02 ,  A61K31/56 ,  A61K31/167 ,  A61K2300/00 ,  A61K31/546 ,  A61K2300/00 ,  A61K31/522 ,  A61K2300/00 ,  A61K31/137 ,  A61K2300/00 ,  A61K31/52 ,  A61K2300/00 ,  A61K31/4164 ,  A61K2300/00

摘要： A tumescent composition comprising a chemotherapy agent in a tumescent solution, wherein a tumescent concentration of the chemotherapy agent is simultaneously below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; and the tumescent solution comprises a vasoconstrictor; a pharmaceutically acceptable carrier; and optionally a local anesthetic.

公开(公告)号：US11696890B2

公开(公告)日：2023-07-11

申请号：US16700740

申请日：2019-12-02

申请人： HK Pharma

发明人： Jeffrey Alan Klein ,  Paytra Alan Klein

IPC分类号： A61K9/00 ,  A61K31/137 ,  A61K9/08 ,  A61K45/06 ,  A61K31/56 ,  A61K31/167 ,  A61K31/522 ,  A61K31/546 ,  A61K31/52 ,  A61K31/4164 ,  A61K47/02

CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4164 ,  A61K31/52 ,  A61K31/522 ,  A61K31/546 ,  A61K45/06 ,  A61K47/02 ,  A61K31/56 ,  A61K31/167 ,  A61K2300/00 ,  A61K31/546 ,  A61K2300/00 ,  A61K31/522 ,  A61K2300/00 ,  A61K31/137 ,  A61K2300/00 ,  A61K31/52 ,  A61K2300/00 ,  A61K31/4164 ,  A61K2300/00

摘要： A tumescent composition comprising a drug or a therapeutic agent in a tumescent solution, wherein a tumescent concentration of the drug or therapeutic agent is simultaneously below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; and the tumescent solution comprises a vasoconstrictor; a pharmaceutically acceptable carrier; and optionally a local anesthetic, wherein the tumescent solution does not comprise an antibiotic.