The invention provides systems and methods for an autonomous vehicle (AV) and cloud control system, which comprises an AV control system comprising an onboard unit (OBU), a roadside unit (RSU) network, and a cloud-based platform. This integrated vehicle-road-cloud system provides traffic state estimation, prediction, computing, and control instructions for specific vehicles by the cloud-based platform. The cloud-based platform also provides safety and efficiency measures for vehicle operations and control under adverse weather conditions, and provides security, redundancy, and resiliency measures to improve system reliability. In addition, the RSU network provides high-resolution maps for specific vehicles.