Disclosed are an anti-drone method using a GPS spoofing signal and a system thereof. According to an embodiment of the inventive concept, an anti-drone method may include injecting a GPS spoofing signal to analyze a drone feature of a target drone and hijacking the target drone by injecting a GPS spoofing signal into the target drone based on a drone hijacking strategy corresponding to the analyzed drone feature among predefined drone hijacking strategies. The analyzing of the drone feature may include injecting the GPS spoofing signal to analyze a safety device mechanism (GPS fail-safe) and a path-following algorithm of the target drone.