- Patent Title: Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto
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Application No.: US14652727Application Date: 2013-12-16
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Publication No.: US11753663B2Publication Date: 2023-09-12
- Inventor: Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
- Applicant: Genomatica, Inc.
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Greenberg Traurig LLP
- International Application: PCT/US2013/075287 2013.12.16
- International Announcement: WO2014/099725A 2014.06.26
- Date entered country: 2015-06-16
- Main IPC: C12P17/10
- IPC: C12P17/10 ; C12P13/02 ; C12P7/24 ; C12P19/02 ; C12P7/44 ; C12P13/00 ; C12N9/04 ; C08G63/78 ; C08G73/02 ; C08G69/16 ; C08G69/08 ; C12N15/52 ; A23L29/00
Abstract:
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
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