Methods, apparatus and articles of manufacture to provide workflow subscription management in a cloud computing environment are disclosed. Examples disclosed herein cause a graphical user interface associated with a virtual appliance to present a template to create a first workflow subscription, the template including (1) a first input element to specify a workflow to be performed, and (2) a second input element to specify an event topic that is to trigger operation of the workflow, the second input element including a field to specify at least one of (i) whether other workflow subscriptions are to be blocked from an event notification associated with the event topic until the first workflow subscription has acted upon the event notification, or (ii) whether a reply notification is to be sent to a service associated with the event notification after the workflow has completed in response to being triggered based on the event notification.