A muting configuration for downlink positioning reference signals (PRS) is based on the slot type in which the PRS is transmitted. A slot type muting configuration mutes PRS if the PRS are transmitted in a full duplex slot, such as an in-band full duplex slot. If the PRS are transmitted in a sub-band full duplex slot, the PRS may be muted depending on whether the base station is capable of self-interference cancellation. The slot type muting configuration does not mute the PRS transmission in a half-duplex slot. The slot type muting configuration may be dynamic and may be provided to a user equipment (UE) in lower layer signaling to improve latency. The slot type muting configuration may be combined with other types of muting configurations, such as inter-instance muting, intra-instance muting, and intra-slot muting, e.g., using a logic function to combine the configurations.