Invention Grant
- Patent Title: Three-dimensional self-assembled nucleic acid nanoparticles and use thereof
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Application No.: US17085089Application Date: 2020-10-30
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Publication No.: US11771777B2Publication Date: 2023-10-03
- Inventor: Dae-Ro Ahn , Thai Bao Dieu Hien
- Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Seoul
- Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Seoul
- Agency: CANTOR COLBURN LLP
- Priority: KR 20190138846 2019.11.01
- Main IPC: A61K47/56
- IPC: A61K47/56 ; A61K47/69 ; A61K31/7105 ; A61P13/12 ; C12N15/113

Abstract:
The present invention relates to three-dimensional self-assembled nucleic acid nanoparticles, a drug delivery system comprising the same, and a pharmaceutical composition for the prevention or treatment of acute kidney injury, which comprises the same. The three-dimensional self-assembled nucleic acid nanoparticles of the present invention, which have a tetrahedral structure, exhibit an excellent renal-targeting ability, and thus the nanoparticles conjugated with the pharmaceutically active ingredient for p53 exhibit excellent p53 and caspase 3 expression reductions in vitro and in vivo, and can thereby be applied to the prevention or treatment of acute kidney injury.
Public/Granted literature
- US20210128748A1 THREE-DIMENSIONAL SELF-ASSEMBLED NUCLEIC ACID NANOPARTICLES AND USE THEREOF Public/Granted day:2021-05-06
Information query
IPC分类: