公开(公告)号：US20210128748A1

公开(公告)日：2021-05-06

申请号：US17085089

申请日：2020-10-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae-Ro AHN ,  Thai Bao Dieu Hien

IPC: A61K47/69 ,  A61K47/56 ,  A61K31/7105 ,  C12N15/113 ,  A61P13/12

Abstract: The present invention relates to three-dimensional self-assembled nucleic acid nanoparticles, a drug delivery system comprising the same, and a pharmaceutical composition for the prevention or treatment of acute kidney injury, which comprises the same. The three-dimensional self-assembled nucleic acid nanoparticles of the present invention, which have a tetrahedral structure, exhibit an excellent renal-targeting ability, and thus the nanoparticles conjugated with the pharmaceutically active ingredient for p53 exhibit excellent p53 and caspase 3 expression reductions in vitro and in vivo, and can thereby be applied to the prevention or treatment of acute kidney injury.

公开(公告)号：US11771777B2

公开(公告)日：2023-10-03

申请号：US17085089

申请日：2020-10-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae-Ro Ahn ,  Thai Bao Dieu Hien

IPC: A61K47/56 ,  A61K47/69 ,  A61K31/7105 ,  A61P13/12 ,  C12N15/113

CPC classification number: A61K47/6931 ,  A61K31/7105 ,  A61K47/56 ,  A61P13/12 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/351

Abstract: The present invention relates to three-dimensional self-assembled nucleic acid nanoparticles, a drug delivery system comprising the same, and a pharmaceutical composition for the prevention or treatment of acute kidney injury, which comprises the same. The three-dimensional self-assembled nucleic acid nanoparticles of the present invention, which have a tetrahedral structure, exhibit an excellent renal-targeting ability, and thus the nanoparticles conjugated with the pharmaceutically active ingredient for p53 exhibit excellent p53 and caspase 3 expression reductions in vitro and in vivo, and can thereby be applied to the prevention or treatment of acute kidney injury.