The present disclosure provides an air conditioning device for a vehicle. The air conditioning device includes an air conditioning unit disposed in at least one of front or rear of the vehicle. The air conditioning device further includes a duct unit blowing air of the air conditioning unit into an interior and extending inside of at least one of a front pillar or a rear pillar. The air conditioning device further includes a vent unit communicating with the duct unit through a connecting duct and selectively opening and closing a discharge path of at least one of a main path, a first path, or a second path so as to discharge the blown air to a side of a roof frame.