An access point allocates resource units within a first channel to mitigate interference from an adjacent second channel. The access point obtains a measure of signal strength corresponding to each wireless device attached to an access point, and assigns, for each wireless device, resource units with a first frequency band of the first channel to mitigate interference with a second frequency band of a second channel adjacent to the first channel. An assignment between a set of resource units and a particular wireless device is based on the measure of signal strength corresponding to the particular wireless device. The access point communicates with the wireless devices on the resource units.