A system and method for controlling a vehicle based on a driver status are disclosed. The vehicle control system includes various sensing devices (including a camera, a vehicle dynamics sensor, a vehicle around view monitoring (AVM) camera, a periphery surveillance sensor, and a navigation device) and an electronic control unit (ECU). The ECU may analyze a driver status through the driver's face and pupils recognized by output signals of the sensing devices. If the driver has no intention to drive the vehicle, the ECU may control the vehicle to stop on a road shoulder, resulting in guarantee of safer driving.