The present disclosure relates to a reinforced thermoplastic bag (e.g., comprising a bag-in-bag). In one or more embodiments, the reinforced thermoplastic bag includes a reinforced portion at a top-of-bag area where users often apply an external force to lift or carry the reinforced thermoplastic bag. In these or other embodiments, a grab-zone reinforcement insert is positioned across one or both of a hem channel region and a grab-zone along an outer surface, an inner surface, or between layers of the reinforced thermoplastic bag. In one or more embodiments, the grab-zone reinforcement insert comprises multiple layers (e.g., of a non-woven material). For example, the grab-zone reinforcement insert includes a first and second layer formed by a fold. In other implementations, the grab-zone reinforcement insert includes separate, discrete layers. In one or more embodiments, at least a portion of the grab-zone reinforcement insert is positionally affixed via a hem seal.