Invention Grant
- Patent Title: Apelin polypeptides
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Application No.: US17160819Application Date: 2021-01-28
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Publication No.: US11807693B2Publication Date: 2023-11-07
- Inventor: Jerry Ryan Holder , Gayathri Swaminath , Michael J. Frohn , Brian Alan Lanman , Anthony B. Reed , Leslie P. Miranda , John Gordon Allen , Alexander J. Pickrell , Aaron C. Siegmund , Lewis D. Pennington , Bryant Yang
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Lisa E. Alexander
- The original application number of the division: US15317911
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K14/47 ; A61K47/54 ; A61K47/60 ; A61K38/10 ; A61K38/00
Abstract:
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
Public/Granted literature
- US20210261619A1 APELIN POLYPEPTIDES Public/Granted day:2021-08-26
Information query
