发明授权
- 专利标题： Apelin polypeptides
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申请号： US17160819申请日： 2021-01-28
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公开(公告)号： US11807693B2公开(公告)日： 2023-11-07
- 发明人: Jerry Ryan Holder , Gayathri Swaminath , Michael J. Frohn , Brian Alan Lanman , Anthony B. Reed , Leslie P. Miranda , John Gordon Allen , Alexander J. Pickrell , Aaron C. Siegmund , Lewis D. Pennington , Bryant Yang
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Lisa E. Alexander
- 分案原申请号： US15317911
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; C07K14/47 ; A61K47/54 ; A61K47/60 ; A61K38/10 ; A61K38/00
摘要：
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
公开/授权文献
- US20210261619A1 APELIN POLYPEPTIDES 公开/授权日：2021-08-26
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