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公开(公告)号：US11807693B2
公开(公告)日：2023-11-07
申请号：US17160819
申请日：2021-01-28
申请人： AMGEN INC.
发明人： Jerry Ryan Holder , Gayathri Swaminath , Michael J. Frohn , Brian Alan Lanman , Anthony B. Reed , Leslie P. Miranda , John Gordon Allen , Alexander J. Pickrell , Aaron C. Siegmund , Lewis D. Pennington , Bryant Yang
CPC分类号： C07K7/08 , A61K38/10 , A61K47/542 , A61K47/60 , C07K14/47 , A61K38/00 , C07K2319/30
摘要： The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号：US11096939B2
公开(公告)日：2021-08-24
申请号：US16428163
申请日：2019-05-31
申请人： Amgen Inc.
发明人： Shon Booker , John Gordon Allen , Brian Alan Lanman , Ryan Paul Wurz , Ning Chen , Victor J. Cee , Patricia Lopez , Aaron C. Siegmund , Michael D. Bartberger
IPC分类号： C07D471/04 , A61K31/497 , C07K16/28
摘要： Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US09328134B2
公开(公告)日：2016-05-03
申请号：US14767737
申请日：2014-02-20
申请人： AMGEN INC.
发明人： John Gordon Allen , Christopher H. Fotsch , Michael J. Frohn , John Douglas McCarter , Mirna Mujacic , Alexander J. Pickrell
IPC分类号： C07D309/10 , C07D309/14 , C07H7/02 , C07K16/28 , C12N5/073
CPC分类号： C07H7/02 , C07D309/10 , C07D309/14 , C07K16/2875 , C07K2317/14 , C07K2317/41 , C12N5/0603 , C12N2501/999 , C12N2510/00
摘要： Compounds of Formula (I) are useful as modulators of glycosylation. Compounds of Formula (I) have the following structure: (I) and the definitions of the other variables are provided herein.
摘要翻译： 式（I）的化合物可用作糖基化的调节剂。 式（I）的化合物具有以下结构：（I），本文提供其它变量的定义。
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公开(公告)号：US11905281B2
公开(公告)日：2024-02-20
申请号：US17031607
申请日：2020-09-24
申请人： Amgen Inc.
发明人： Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , David John Kopecky , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Nobuko Nishimura , Youngsook Shin , Nuria A. Tamayo , John Gordon Allen , Jennifer Rebecca Allen
IPC分类号： C07D471/04 , C07D213/82 , C07D417/04 , A61K38/07 , C07D487/08 , C07D417/12 , C07D513/04 , C07D487/10 , C07D487/04 , C07D401/04 , C07D239/80 , C07D401/14 , C07D237/34 , C07D403/04 , A61K31/496 , A61K31/416 , A61K31/55 , A61K31/454 , A61K31/519 , A61K31/502 , A61K31/517 , A61K31/5025 , A61P35/00 , A61K31/7068 , C07D275/04 , C07D475/00
CPC分类号： C07D417/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/7068 , A61K38/07 , A61P35/00 , C07D237/34 , C07D239/80 , C07D275/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D417/12 , C07D471/04 , C07D475/00 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20150376221A1
公开(公告)日：2015-12-31
申请号：US14767737
申请日：2014-02-20
申请人： AMGEN INC.
发明人： John Gordon Allen , Christopher H. FOTSCH , Michael J. FROHN , John Douglas MCCARTER , Mirna MUJACIC , Alexander J. PICKRELL
CPC分类号： C07H7/02 , C07D309/10 , C07D309/14 , C07K16/2875 , C07K2317/14 , C07K2317/41 , C12N5/0603 , C12N2501/999 , C12N2510/00
摘要： Compounds of Formula (I) are useful as modulators of glycosylation. Compounds of Formula (I) have the following structure: (I) and the definitions of the other variables are provided herein.
摘要翻译： 式（I）的化合物可用作糖基化的调节剂。 式（I）的化合物具有以下结构：（I），本文提供其它变量的定义。
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公开(公告)号：US11732266B2
公开(公告)日：2023-08-22
申请号：US17080771
申请日：2020-10-26
申请人： AMGEN INC.
发明人： Michael Ollmann , Yang Li , Jun Zhang , Oliver Homann , Leslie P. Miranda , Justin K. Murray , Bin Wu , Oh Kyu Yoon , John Gordon Allen , Chawita Netirojjanakul , Yuan Cheng
IPC分类号： C12N15/113 , A61P9/10 , A61P3/06 , C07K16/28
CPC分类号： C12N15/1138 , A61P3/06 , A61P9/10 , C07K16/2851 , C07K2317/526 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/351 , C12N2310/3513 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533 , C12N2310/322 , C12N2310/3531
摘要： The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.
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公开(公告)号：US11090304B2
公开(公告)日：2021-08-17
申请号：US16402538
申请日：2019-05-03
申请人： Amgen Inc.
发明人： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman
IPC分类号： A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US10519146B2
公开(公告)日：2019-12-31
申请号：US15984855
申请日：2018-05-21
申请人： Amgen Inc.
发明人： Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , David John Kopecky , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Nobuko Nishimura , Youngsook Shin , Nuria A. Tamayo , John Gordon Allen , Jennifer Rebecca Allen
IPC分类号： C07D471/04 , C07D487/04 , C07D403/04 , C07D401/04 , C07D475/00 , A61K31/496 , A61K31/519 , A61P35/00 , C07D417/04 , A61K38/07 , C07D487/08 , C07D417/12 , C07D513/04 , C07D487/10 , C07D239/80 , C07D401/14 , C07D237/34 , A61K31/416 , A61K31/55 , A61K31/454 , A61K31/517 , A61K31/502 , A61K31/5025 , A61K31/7068 , C07D275/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US12083121B2
公开(公告)日：2024-09-10
申请号：US17579359
申请日：2022-01-19
申请人： AMGEN INC.
发明人： John Gordon Allen , Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Jennifer Rebecca Allen , Margaret Chu-Moyer , Albert Amegadzie , Ning Chen , Clifford Goodman , Jonathan D. Low , Vu Van Ma , Ana Elena Minatti , Nobuko Nishimura , Alexander J. Pickrell , Hui-Ling Wang , Youngsook Shin , Aaron C. Siegmund , Kevin C. Yang , Nuria A. Tamayo , Mary Walton , Qiufen Xue
IPC分类号： C07D241/04 , A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
CPC分类号： A61K31/519 , A61K31/551 , A61K39/39558 , A61P35/00
摘要： Provided herein are KRAS G12C inhibitors, such as
composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.-
公开(公告)号：US11766436B2
公开(公告)日：2023-09-26
申请号：US17363878
申请日：2021-06-30
申请人： Amgen Inc.
发明人： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman
IPC分类号： A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
CPC分类号： A61K31/517 , A61K31/4985 , A61K39/39558 , A61P35/00 , C07D403/04 , C07D471/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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