An electronic device with a connector supporting multiple connection standards includes the connector, a first multiplexer circuit, a processor and a controller. The connector includes a detection pin and at least one signal pin. The first multiplexer circuit is coupled to the at least one signal pin. The processor is coupled to the first multiplexer circuit. The controller monitors the detection pin. The first multiplexer circuit electrically connects the at least one signal pin to the controller. Upon detecting a hot-plug signal occurring at the detection pin, the controller issues a confirmation command via the first multiplexer circuit and the at least one signal pin to request a reply of a device signal. Upon receiving the device signal, the controller controls the first multiplexer circuit according to the device signal to electrically connect the at least one signal pin to the processor or the controller.