Systems, apparatuses, and methods for maintaining a region-based cache directory are disclosed. A system includes multiple processing nodes, with each processing node including a cache subsystem. The system also includes a cache directory to help manage cache coherency among the different cache subsystems of the system. In order to reduce the number of entries in the cache directory, the cache directory tracks coherency on a region basis rather than on a cache line basis, wherein a region includes multiple cache lines. Accordingly, the system includes a region-based cache directory to track regions which have at least one cache line cached in any cache subsystem in the system. The cache directory includes a reference count in each entry to track the aggregate number of cache lines that are cached per region. If a reference count of a given entry goes to zero, the cache directory reclaims the given entry.