A portable information handling system housing integrates a display having an edge-to-edge presentation of visual images at a housing portion with an inactive portion of a display panel along a perimeter of the display having a sensor region that provides access to underlying sensors through the display. A sealant and black matrix disposed in the inactive region limits illumination that escapes from an active region and provides an aesthetically appealing edge-to-edge appearance. Openings in the sealant and black matrix at the sensor locations provides access through the display, such as with index matching resin that passes illumination and a patterned covering of the black matrix.