- 专利标题: CAR T-cells comprising transcriptional circuits
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申请号: US16759222申请日: 2018-10-24
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公开(公告)号: US11851672B2公开(公告)日: 2023-12-26
- 发明人: Martin Pulé , James Sillibourne , Shaun Cordoba
- 申请人: AUTOLUS LIMITED
- 申请人地址: GB London
- 专利权人: AUTOLUS LIMITED
- 当前专利权人: AUTOLUS LIMITED
- 当前专利权人地址: GB London
- 代理机构: MARSHALL, GERSTEIN & BORUN LLP
- 优先权: GB 17524 2017.10.25
- 国际申请: PCT/GB2018/053088 2018.10.24
- 国际公布: WO2019/081935A 2019.05.02
- 进入国家日期: 2020-04-24
- 主分类号: C12N15/86
- IPC分类号: C12N15/86 ; A61K35/17 ; A61K48/00
摘要:
The present invention provides a kit of vectors for transducing an immune cell with multiple transgenes comprising: (i) a first vector which comprises a first transgene and a nucleotide sequence encoding a transcription factor and; and (ii) a second vector which comprises a second transgene wherein expression of the second transgene within a host cell is dependent upon expression of the transcription factor.
公开/授权文献
- US20200308600A1 VECTORS 公开/授权日:2020-10-01
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