Systems and methods for mitigating exhaust gas emissions via cylinder deactivation are provided. A system includes a controller coupled to an internal combustion engine and an electric motive device. The controller includes a processor and a memory. The memory stores instruction that, when executed by the processor, cause the controller to: receive a power request less than a current power output from the internal combustion engine; command the electric motive device to provide a supplemental power output based on the received power request; command the internal combustion engine to operate in a cylinder deactivation mode whereby at least one cylinder of a plurality of cylinders of the internal combustion engine is deactivated; responsive to determining that a power output of the internal combustion engine is substantially equivalent to the power request after commanding the internal combustion engine to operate in the cylinder deactivation mode, deactivate the electric motive device.