Single slot cradles with interchangeable tops are disclosed herein. An example cradle includes a base assembly including a coupling mechanism, a top housing assembly operably coupled with the coupling mechanism, a circuit board assembly, and a first cup assembly. The top housing assembly includes a housing opening. The circuit board assembly is at least partially disposed within the housing opening and includes a board communication interface and at least one of a power interface or a data connection interface. The first cup assembly removably couples with at least one of the base assembly or the top housing assembly and includes at least one dock to operably couple with a handheld scanning device and further includes a cup communication interface. The board communication interface communicatively couples with the cup communication interface to allow transmission between at least one of the power interface or the data interface and the handheld scanning device.