- 专利标题： Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops
-
申请号： US16476868申请日： 2018-01-09
-
公开(公告)号： US11873496B2公开(公告)日： 2024-01-16
- 发明人: Richard A. Young , Abraham S. Weintraub , Charles H. Li , Alla A. Sigova
- 申请人： Whitehead Institute for Biomedical Research
- 申请人地址： US MA Cambridge
- 专利权人： Whitehead Institute for Biomedical Research
- 当前专利权人： Whitehead Institute for Biomedical Research
- 当前专利权人地址： US MA Cambridge
- 代理机构： Morse, Barnes-Brown & Pendleton, P.C.
- 代理商 Lisa M. Warren, Esq.; Erin E. Bryan, Esq.
- 国际申请： PCT/US2018/013003 2018.01.09
- 国际公布： WO2018/129544A 2018.07.12
- 进入国家日期： 2019-07-09
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C12N15/67 ; C07K14/47 ; C12N15/113 ; G01N33/50 ; C12N15/85
摘要：
The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.
公开/授权文献
信息查询
