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公开(公告)号：US11873496B2
公开(公告)日：2024-01-16
申请号：US16476868
申请日：2018-01-09
CPC分类号： C12N15/67 , C07K14/4702 , C12N15/113 , C12N15/85 , G01N33/5023 , C12N2015/859 , C12N2310/51 , C12N2310/53 , C12N2830/001 , C12N2830/15
摘要： The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.
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2.发明申请公开(公告)号：US20190352648A1
公开(公告)日：2019-11-21
申请号：US16476868
申请日：2018-01-09
IPC分类号： C12N15/67 , C07K14/47 , C12N15/113 , G01N33/50 , C12N15/85
摘要： The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.
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公开(公告)号：US20190062752A1
公开(公告)日：2019-02-28
申请号：US15771913
申请日：2016-10-28
IPC分类号： C12N15/113
摘要： Disclosed herein are methods useful for modulating expression of a target gene by modulating binding between a ribonucleic acid (RNA) transcribed from at least one regulatory element of a target gene and a transcription factor which binds to both the RNA and the regulatory element. Also disclosed herein are methods and assays for identifying agents that interfere with binding between RNA transcribed from at least one regulatory element and a transcription factor which binds to the RNA and to the regulatory element.
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4.发明公开公开(公告)号：US20240263184A1
公开(公告)日：2024-08-08
申请号：US18540829
申请日：2023-12-14
IPC分类号： C12N15/67 , C07K14/47 , C12N15/113 , C12N15/85 , G01N33/50
CPC分类号： C12N15/67 , C07K14/4702 , C12N15/113 , C12N15/85 , G01N33/5023 , C12N2015/859 , C12N2310/51 , C12N2310/53 , C12N2830/001 , C12N2830/15
摘要： The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.
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公开(公告)号：US20210269805A1
公开(公告)日：2021-09-02
申请号：US17217612
申请日：2021-03-30
IPC分类号： C12N15/113 , C12N15/63 , C12N15/10
摘要： Disclosed herein are methods useful for modulating expression of a target gene by modulating binding between a ribonucleic acid (RNA) transcribed from at least one regulatory element of a target gene and a transcription factor which binds to both the RNA and the regulatory element. Also disclosed herein are methods and assays for identifying agents that interfere with binding between RNA transcribed from at least one regulatory element and a transcription factor which binds to the RNA and to the regulatory element.
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