Invention Grant
- Patent Title: ASH1L inhibitors and methods of treatment therewith
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Application No.: US16300421Application Date: 2017-05-12
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Publication No.: US11883381B2Publication Date: 2024-01-30
- Inventor: Jolanta Grembecka , Tomasz Cierpicki , David Rogawski , Dmitry Borkin , Szymon Klossowski , Zhuang Jin , Deanna Montgomery , Jing Deng , Marta Krotoska , Hao Li
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agent David W. Staple
- International Application: PCT/US2017/032365 2017.05.12
- International Announcement: WO2017/197240A 2017.11.16
- Date entered country: 2018-11-09
- Main IPC: A61K31/404
- IPC: A61K31/404 ; A61K45/06 ; C07D209/18 ; C07D209/08 ; A61P35/02
Abstract:
Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
Public/Granted literature
- US20190142799A1 ASH1L INHIBITORS AND METHODS OF TREATMENT THEREWITH Public/Granted day:2019-05-16
Information query
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