专利检索 ap:("The Regents of the University of Michigan") AND inv:"David Rogawski" 第 1 页

1.

发明授权
ASH1L inhibitors and methods of treatment therewith 有权

公开(公告)号：US11883381B2

公开(公告)日：2024-01-30

申请号：US16300421

申请日：2017-05-12

申请人： The Regents of the University of Michigan

发明人： Jolanta Grembecka , Tomasz Cierpicki , David Rogawski , Dmitry Borkin , Szymon Klossowski , Zhuang Jin , Deanna Montgomery , Jing Deng , Marta Krotoska , Hao Li

IPC分类号： A61K31/404 , A61K45/06 , C07D209/18 , C07D209/08 , A61P35/02

CPC分类号： A61K31/404 , A61K45/06 , A61P35/02 , C07D209/08 , C07D209/18

摘要： Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

2.

发明申请
ASH1L INHIBITORS AND METHODS OF TREATMENT THEREWITH 审中-公开

公开(公告)号：US20190142799A1

公开(公告)日：2019-05-16

申请号：US16300421

申请日：2017-05-12

申请人： The Regents of the University of Michigan

发明人： Jolanta Grembecka , Tomasz Cierpicki , David Rogawski , Dmitry Borkin , Szymon Klossowski , Jin Zhuang , Deanna Montgomery

IPC分类号： A61K31/404 , A61P35/02

摘要： Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.