- Patent Title: Synthetic immunomodulation with a CRISPR super-repressor in vivo
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Application No.: US17292407Application Date: 2019-11-07
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Publication No.: US11884925B2Publication Date: 2024-01-30
- Inventor: Samira Kiani , Mo Reza Ebrahimkhani , Farzaneh Moghadam
- Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Applicant Address: US AZ Scottsdale
- Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Current Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Current Assignee Address: US AZ Scottsdale
- Agency: Quarles & Brady, LLP
- International Application: PCT/US2019/060285 2019.11.07
- International Announcement: WO2020/097344A 2020.05.14
- Date entered country: 2021-05-07
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C07K14/47 ; C12N9/22 ; C12N15/11 ; C12N15/86 ; A61K48/00
Abstract:
Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia.
Public/Granted literature
- US20210380990A1 SYNTHETIC IMMUNOMODULATION WITH A CRISPR SUPER-REPRESSOR IN VIVO Public/Granted day:2021-12-09
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