Provided are a PDCCH monitoring method and device of a DRX-configured terminal in a wireless communication system. In the method, if a monitoring occasion is present in a monitoring window for monitoring DCI (WUS) comprising a wake-up indication, the WUS is monitored in the monitoring occasion and, if the WUS is detected, the relevant operation is performed in a DRX ON duration on the basis of same. The WUS can indicate whether or not to wake up from a plurality of DRX cycles. Also, the WUS can indicate various configurations in accordance with the length of the DRX cycles. If the monitoring occasion is not present in the monitoring window, the terminal wakes up from a DRX cycle linked to the monitoring occasion and performs PDCCH monitoring for a general DCI detection not comprising a wake-up indication.