Invention Grant
- Patent Title: Methods of treating ocular disorders by administering a VEGF-binding antibody covalently linked to a hyaluronic acid polymer
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Application No.: US17392943Application Date: 2021-08-03
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Publication No.: US11891437B2Publication Date: 2024-02-06
- Inventor: Amin Famili , Germaine Fuh , Patrick Koenig , Chingwei Vivian Lee , Karthikan Rajagopal
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Clark & Elbing LLP
- Agent Karen L. Elbing
- The original application number of the division: US16572822 2019.09.17
- Main IPC: C07K16/22
- IPC: C07K16/22 ; A61K47/61 ; A61K9/00 ; A61K9/06 ; A61K9/08
Abstract:
The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).
Public/Granted literature
- US20210363231A1 OPTIMIZED ANTIBODY COMPOSITIONS FOR TREATMENT OF OCULAR DISORDERS Public/Granted day:2021-11-25
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