- 专利标题： Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
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申请号： US16854190申请日： 2020-04-21
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公开(公告)号： US11891625B2公开(公告)日： 2024-02-06
- 发明人: Derrick J. Rossi , Wataru Ebina , Morag Stewart , Paula Gutierrez-Martinez , Lee L Rubin , Lance Davidow
- 申请人： CHILDREN'S MEDICAL CENTER CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 申请人地址： US MA Boston
- 专利权人： CHILDREN'S MEDICAL CENTER CORPORATION,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人： CHILDREN'S MEDICAL CENTER CORPORATION,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人地址： US MA Boston
- 代理机构： NIXON PEABODY LLP
- 代理商 David S. Resnick; Nicole D. Kling
- 主分类号： C12N5/0789
- IPC分类号： C12N5/0789 ; A61K35/28 ; A61K38/19 ; C12N15/86 ; C07K14/495
摘要：
The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGFβ signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
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