Invention Grant
- Patent Title: Methods of detecting renal transplant rejection using microvesicle nucleic acid biomarkers
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Application No.: US16613298Application Date: 2018-05-16
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Publication No.: US11891664B2Publication Date: 2024-02-06
- Inventor: James Hurley , Christine Coticchia , Robert Kitchen , Vasisht Tadigotla , Johan Karl Olov Skog , Jamil Azzi
- Applicant: Exosome Diagnostics, Inc. , The Brigham and Women's Hospital
- Applicant Address: US MA Waltham
- Assignee: Exosome Diagnostics, Inc.,The Brigham and Women's Hospital
- Current Assignee: Exosome Diagnostics, Inc.,The Brigham and Women's Hospital
- Current Assignee Address: US MA Waltham; US MA Boston
- Agency: COOLEY LLP
- Agent Ivor R. Elrifi; Matthew Pavao
- International Application: PCT/US2018/032888 2018.05.16
- International Announcement: WO2018/213392A 2018.11.22
- Date entered country: 2019-11-13
- Main IPC: C12Q1/6883
- IPC: C12Q1/6883 ; G01N1/28 ; G01N33/68
Abstract:
The invention relates generally to the use of microvesicle biomarkers such as nucleic acids, including nucleic acid signatures, and/or proteins for assessing a kidney transplant rejection in a patient. The invention further relates to assessing, and/or to monitoring kidney transplant rejection in patients who have received a renal transplant.
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