- 专利标题： PEM layer-by-layer systems for coating substrates to improve bioactivity and biomolecule delivery
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申请号： US17495543申请日： 2021-10-06
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公开(公告)号： US11898055B2公开(公告)日： 2024-02-13
- 发明人: Prashant N. Kumta , Sangeetha Kunjukunju , Nicole J. Ostrowski , Abhijit Roy , Boeun Lee , Madhumati Ramanathan
- 申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- 申请人地址： US PA Pittsburgh
- 专利权人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- 当前专利权人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- 当前专利权人地址： US PA Pittsburgh
- 代理机构： Eckert Seamans Cherin & Mellott, LLC
- 代理商 Carol A. Marmo
- 分案原申请号： US14778331
- 主分类号： C09D177/04
- IPC分类号： C09D177/04 ; A61F2/02 ; A61L27/04 ; A61L27/34 ; A61L27/54 ; A61L27/58 ; B05D7/00 ; C09D105/04 ; C09D167/04
摘要：
The invention relates to polyelectrolyte multilayer coatings and, methods for their preparation and application to substrates to enhance the bioactivity and corrosion protection of the substrates' surface. The invention is particularly suitable for coating substrates employed for medical applications, such as but not limited to medical implant devices for drug and/or biologics delivery in a patient. The substrate has a positive or negative charge. The polyelectrolyte multilayer coatings include at least a first polymer layer and a second polymer layer. The first polymer and second polymer have opposite charges. Each of the polymer layers is individually applied using a layer-by-layer such that an alternating charge multilayer coating is formed.
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