Methods for assessing a skin surface of a patient and associated systems and devices are described herein. A method configured in accordance with embodiments of the present technology can include, for example, receiving a three-dimensional data set representative of the patient's skin surface and determining a boundary of a feature of the patient's skin in the three-dimensional data set. The method can further include determining, with a processor, a three-dimensional surface area of the feature within the boundary. In some embodiments, the method can also include identifying a plurality of sub-regions within the boundary and identifying one or more tissue types in each sub-region.