- 专利标题: Immunocompetent cell and expression vector expressing regulatory factors of immune function
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申请号: US17748889申请日: 2022-05-19
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公开(公告)号: US11931381B2公开(公告)日: 2024-03-19
- 发明人: Koji Tamada , Yukimi Sakoda , Keishi Adachi
- 申请人: Yamaguchi University
- 申请人地址: JP Yamaguchi
- 专利权人: YAMAGUCHI UNIVERSITY
- 当前专利权人: YAMAGUCHI UNIVERSITY
- 当前专利权人地址: JP Yamaguchi
- 代理机构: Morgan, Lewis & Bockius LLP
- 优先权: JP 16053913 2016.03.17
- 主分类号: C12N5/10
- IPC分类号: C12N5/10 ; A61K35/17 ; A61K39/00 ; C07K14/54 ; C07K14/725 ; C12N5/0783 ; C12N15/09 ; C12N15/79
摘要:
It is to provide an immunocompetent cell that expresses regulatory factors of immunocompetent cell immune function and possesses all of proliferative potential, viability, and the ability to accumulate a T cell, and an expression vector of regulatory factors of immune function for generating the immunocompetent cell. An immunocompetent cell expressing a cell surface molecule specifically recognizing a cancer antigen, interleukin 7 (IL-7), and CCL19 is generated. Preferably, the cell surface molecule specifically recognizing a cancer antigen is T cell receptor specifically recognizing the cancer antigen, and the immunocompetent cell is a T cell.
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