The present disclosure provides a voltage reference source circuit for generating a reference voltage, the voltage reference source circuit comprises a starting circuit, a current generating circuit, and an output voltage reference circuit electrically connected in sequence. The starting circuit provides a starting voltage for the voltage reference source circuit to prevent the voltage reference source circuit from operating in zero state area. The current generating circuit generates a working current for the output voltage reference circuit; and the output voltage reference circuit is used to realize the reference voltage output with zero temperature coefficient according to the working current output by the current generating circuit. A low power consumption power supply system is also disclosed. The voltage reference source circuit and the low power consumption power supply system with the voltage reference source circuit have simple circuit structure, strong anti-noise ability, high stability and high performance.