Invention Grant
- Patent Title: Benzisoxazole compound
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Application No.: US18073180Application Date: 2022-12-01
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Publication No.: US11976062B2Publication Date: 2024-05-07
- Inventor: Ryu Nagata , Yasuo Mori , Masayuki Mori , Motohiro Nishida , Takuro Tomita
- Applicant: OSAKA UNIVERSITY , KYOTO UNIVERSITY , INTER-UNIVERSITY RESEARCH INSTITUTE CORP NATIONAL INSTITUTES OF NATURAL SCIENCES
- Applicant Address: JP Osaka
- Assignee: OSAKA UNIVERSITY,KYOTO UNIVERSITY,INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES
- Current Assignee: OSAKA UNIVERSITY,KYOTO UNIVERSITY,INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES
- Current Assignee Address: JP Suita; JP Kyoto; JP Mitaka
- Agency: MH2 TECHNOLOGY LAW GROUP, LLP
- Priority: JP 18086929 2018.04.27
- The original application number of the division: US17050070
- Main IPC: C07D413/12
- IPC: C07D413/12 ; A61P43/00 ; C07D261/20 ; C07D413/04 ; C07D413/14 ; C07D417/12 ; C07D487/08

Abstract:
The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1)
(wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom, of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).
(wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom, of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).
Public/Granted literature
- US20230114195A1 BENZISOXAZOLE COMPOUND Public/Granted day:2023-04-13
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