An RF fingerprint signal processing device configured for executing a machine learning algorithm on a plurality of input signals. The RF fingerprint signal processing device includes a receiver-feature determination circuit and a classifying determination circuit. The receiver-feature determination circuit is configured to compute on the plurality of input signals in a neural network. The classifying determination circuit is coupled with the receiver-feature determination circuit, and the classifying determination circuit is configured to send feedback information of a receiver-feature component to the receiver-feature determination circuit. The receiver-feature determination circuit decreases the receiver-feature weight of the neural network. The receiver-feature weight is associated with the receiver-feature component, and the receiver-feature weight which is decreased is applied for computing an output value of the neural network.