- 专利标题： Methods of treating solid tumors with CCR2 antagonists
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申请号： US17128500申请日： 2020-12-21
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公开(公告)号： US11986466B2公开(公告)日： 2024-05-21
- 发明人: James J. Campbell , Rajinder Singh , Samuel Hwang , Xuesong Wu
- 申请人： CHEMOCENTRYX, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 申请人地址： US CA Mountain View
- 专利权人： CHEMOCENTRYX, INC.
- 当前专利权人： CHEMOCENTRYX, INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo PC
- 主分类号： A61K31/4433
- IPC分类号： A61K31/4433 ; A61K31/496 ; A61K39/395 ; A61P35/00 ; C07K16/28
摘要：
The present disclosure provides, inter alia, methods of treating a solid-tumor by administering an effective amount of a Chemokine Receptor 2 (CCR2) antagonist. Also provided herein are methods of reducing the number of macrophages in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In an additional aspect, the current disclosure further provides methods of increasing the number CD8+ T cells in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In some embodiments, the CCR2 antagonist has the formula I or Formula III:
公开/授权文献
- US20210346361A1 METHODS OF TREATING SOLID TUMORS WITH CCR2 ANTAGONISTS 公开/授权日：2021-11-11
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