A wheelchair that prevents the secondary transmission of germs, including a seat, a drive mechanism, antibacterial fabric, and a dirt-retaining board. The drive mechanism is symmetrically provided about the seat. The drive mechanism includes a frame, front wheels, rear wheels, and drive wheels. The frame is fixedly connected to the seat. The front wheels, the rear wheels, and the drive wheels are all rotated and set on the frame. The drive wheels are not coaxial with the front wheels and rear wheels and do not interfere with each other. Drive wheels are connected to the rear wheels by transmission. The dirt-retaining boards are installed on the rear wheels in coordination. The active wheels, the seat, the armrests, and the push handles are sleeved thereon with antimicrobial fabric.