- 专利标题： Polymerase mutants and use with 3′-OH unblocked reversible terminators
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申请号： US18464955申请日： 2023-09-11
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公开(公告)号： US12006519B2公开(公告)日： 2024-06-11
- 发明人: Michelle Cayouette , Jeffrey Fox , Connie Hansen , Holly Hogrefe , Weidong Wu
- 申请人： Agilent Technologies, Inc.
- 申请人地址： US CA Santa Clara
- 专利权人： Agilent Technologies, Inc.
- 当前专利权人： Agilent Technologies, Inc.
- 当前专利权人地址： US CA Santa Clara
- 主分类号： C12N9/12
- IPC分类号： C12N9/12 ; C12P19/34 ; C12Q1/6869
摘要：
Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′-OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.
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