A system for collecting a physiological sample includes a dermal patch configured for attaching to a subject's skin and an applicator for coupling to the dermal patch. The dermal patch includes a reservoir configured to store a processing fluid, a sample collection chamber for receiving the processing fluid and a physiological sample extracted from a subject. The applicator includes at least one actuating lever for activating the dermal patch to receive the physiological sample from the subject and directing the physiological sample into the sample collection chamber.