Described herein is a system and method for detecting malodor within a cabin of an autonomous vehicle, wherein initiation of a remediation system and/or dispatch of the autonomous vehicle to a service hub for mitigating the malodor is based upon sensor signals that monitor the cabin of the autonomous vehicle. The remediation system can include devices such as an HVAC system or a window, which are operated to reduce the concentration of airborne molecules in the cabin of the autonomous vehicle when the concentration of airborne molecules exceeds an air quality threshold. A dispatch protocol may be initiated to dispatch the autonomous vehicle to a service hub when the malodor is associated with certain predefined incidents or when remediation fails to reduce the concentration of airborne molecules below the air quality threshold.