Invention Grant
- Patent Title: Polyvalent sting activating compositions and uses thereof
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Application No.: US17469111Application Date: 2021-09-08
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Publication No.: US12036319B2Publication Date: 2024-07-16
- Inventor: Jinming Gao , Suxin Li
- Applicant: The Board of Regents of the University of Texas System
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of The University of Texas System
- Current Assignee: The Board of Regents of The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- Main IPC: A61K9/107
- IPC: A61K9/107 ; A61K31/4184 ; A61K31/5377 ; A61K31/7076 ; A61K47/32 ; A61P35/00
Abstract:
Described herein are therapeutic pH responsive compositions useful for the treatment of cancer. The compositions involve combining a STING activating polymer micelle, such as PC7A, with a non-peptide STING agonist, such as cGAMP. Methods of administering these compositions in the treatment of cancer are also disclosed. These methods include administration of the pharmaceutical compositions by intratumoral injection in the treatment of solid tumors.
Public/Granted literature
- US20220071903A1 POLYVALENT STING ACTIVATING COMPOSITIONS AND USES THEREOF Public/Granted day:2022-03-10
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