- 专利标题： Modified double-stranded donor templates
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申请号： US17079097申请日： 2020-10-23
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公开(公告)号： US12037615B2公开(公告)日： 2024-07-16
- 发明人: Jessica Woodley , Bernice Thommandru , Joseph Dobosy , Mark Behlke , Adam Clore , Garrett Rettig , Beimeng Sun
- 申请人： INTEGRATED DNA TECHNOLOGIES, INC.
- 申请人地址： US IA Coralville
- 专利权人： INTEGRATED DNA TECHNOLOGIES, INC.
- 当前专利权人： INTEGRATED DNA TECHNOLOGIES, INC.
- 当前专利权人地址： US IA Coralville
- 代理机构： Michael Best & Friedrich LLP
- 主分类号： C12N15/66
- IPC分类号： C12N15/66 ; C12N9/22 ; C12N15/113
摘要：
Described herein are compositions and methods for improving homology directed repair (HDR) efficiency and reducing homology-independent integration following introduction of double strand breaks with engineered nucleases. Additionally, modifications to double stranded DNA donors to improve the donor potency and efficiency of homology directed repair following introduction of double stranded breaks with programmable nucleases.
公开/授权文献
- US12123033B2 Modified double-stranded donor templates 公开/授权日：2024-10-22
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