Various methods and systems are provided for x-ray imaging. In one embodiment, a method includes acquiring, with an x-ray detector, an x-ray image of a subject, determining a transformation that minimizes anti-scatter grid artifacts in the x-ray image, correcting the x-ray image according to the transformation to generate a corrected image, and outputting the corrected image. In this way, artifacts arising from a misalignment of an anti-scatter grid between the calibration and the acquisition may be reduced.