- 专利标题： Compound useful for the treatment of degenerative and inflammatory diseases
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申请号： US17230483申请日： 2021-04-14
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公开(公告)号： US12042498B2公开(公告)日： 2024-07-23
- 发明人: Christel Jeanne Marie Menet , Koen Kurt Smits
- 申请人： Alfasigma S.p.A.
- 申请人地址： IT Bologna
- 专利权人： ALFASIGMA S.P.A.
- 当前专利权人： ALFASIGMA S.P.A.
- 当前专利权人地址： IT Bologna
- 代理机构： Culhane PLLC
- 代理商 Jeff B. Vockrodt
- 主分类号： A61K31/541
- IPC分类号： A61K31/541 ; A61K45/06 ; C07D471/04
摘要：
A novel compound able to inhibit JAK is disclosed, that comprises a compound of Formula I:
The compound may be prepared as a pharmaceutical composition, and may be used for the treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
The compound may be prepared as a pharmaceutical composition, and may be used for the treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
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