公开(公告)号：US20240325405A1

公开(公告)日：2024-10-03

申请号：US18741974

申请日：2024-06-13

申请人： ALFASIGMA S.P.A.

发明人： Christel Jeanne Marie Menet ,  Koen Kurt Smits

IPC分类号： A61K31/541 ,  A61K45/06 ,  C07D471/04

CPC分类号： A61K31/541 ,  A61K45/06 ,  C07D471/04

摘要： A novel compound able to inhibit JAK is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.

公开(公告)号：US12042498B2

公开(公告)日：2024-07-23

申请号：US17230483

申请日：2021-04-14

申请人： Alfasigma S.p.A.

发明人： Christel Jeanne Marie Menet ,  Koen Kurt Smits

IPC分类号： A61K31/541 ,  A61K45/06 ,  C07D471/04

CPC分类号： A61K31/541 ,  A61K45/06 ,  C07D471/04

摘要： A novel compound able to inhibit JAK is disclosed, that comprises a compound of Formula I:




The compound may be prepared as a pharmaceutical composition, and may be used for the treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.