- 专利标题： 10E8 neutralizing antibody variants that bind to the MPER region of HIV-1 GP41 and their use
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申请号： US17551066申请日： 2021-12-14
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公开(公告)号： US12043660B2公开(公告)日： 2024-07-23
- 发明人: Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Trustees of Columbia University in the City of New York
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,The Trustees of Columbia University in the City of New York
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,The Trustees of Columbia University in the City of New York
- 当前专利权人地址： US MD Bethesda; US NY New York
- 代理机构： Klarquist Sparkman, LLP
- 分案原申请号： US15772443
- 主分类号： C07K16/10
- IPC分类号： C07K16/10 ; A61P31/18
摘要：
Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
公开/授权文献
- US20220098286A1 NEUTRALIZING ANTIBODIES TO HIV-1 GP41 AND THEIR USE 公开/授权日：2022-03-31
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