- 专利标题： Genetic probe for the detection of a single nucleotide polymorphism (SNP) or a single nucleotide modification of a target nucleic acid
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申请号： US16643133申请日： 2018-08-09
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公开(公告)号： US12043865B2公开(公告)日： 2024-07-23
- 发明人: James Tucker , Zoe Pikramenou , Andrew Beggs , Zsusa Nagy , Purbani Chakrabarti
- 申请人： The University of Birmingham
- 申请人地址： GB Birmingham
- 专利权人： The University of Birmingham
- 当前专利权人： The University of Birmingham
- 当前专利权人地址： GB Birmingham
- 代理机构： NIXON PEABODY LLP
- 代理商 Mark J. Fitzgerald; Nicole D. Kling
- 优先权： GB 14068 2017.09.01
- 国际申请： PCT/GB2018/052275 2018.08.09
- 国际公布： WO2019/043353A 2019.03.07
- 进入国家日期： 2020-02-28
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C12Q1/6827 ; C12Q1/6876
摘要：
The present invention relates to a genetic probe comprising:
a nanoparticle;
an oligonucleotide probe anchored to the surface of the nanoparticle, comprising an oligonucleotide backbone with a tag incorporated therein via a linker group; and
a reference probe anchored to the surface of the nanoparticle, wherein the reference probe comprises a marker;
wherein either (a) the tag is an organic fluorescent tag and the marker is a transition metal-based fluorescent marker; or (b) the tag is a redox-active tag and the marker is a transition metal-based redox-active marker. The invention also relates to a composition or kit containing a probe of the invention.
a nanoparticle;
an oligonucleotide probe anchored to the surface of the nanoparticle, comprising an oligonucleotide backbone with a tag incorporated therein via a linker group; and
a reference probe anchored to the surface of the nanoparticle, wherein the reference probe comprises a marker;
wherein either (a) the tag is an organic fluorescent tag and the marker is a transition metal-based fluorescent marker; or (b) the tag is a redox-active tag and the marker is a transition metal-based redox-active marker. The invention also relates to a composition or kit containing a probe of the invention.
公开/授权文献
- US20200332349A1 SENSOR 公开/授权日：2020-10-22
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