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公开(公告)号：US20240350704A1
公开(公告)日：2024-10-24
申请号：US18701733
申请日：2022-10-20
CPC分类号： A61L27/10 , A61L27/3847 , A61L2300/104 , A61L2300/112 , A61L2430/02
摘要： A method of forming an implant for the repair of defects in bone. the method comprises the steps of: electrospinning bioactive glass fibres: compressing the electrospun bioactive glass fibres to form a compressed body: heating the compressed body to bond the fibres to form a shaped body: heat treating the shaped body to form a heat-treated shaped body. There is also disclosed an implant for use in repairing critical or sub critical bone defects.
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公开(公告)号：US20240319402A1
公开(公告)日：2024-09-26
申请号：US18491841
申请日：2022-04-26
摘要： An apparatus for driving atoms of an atom cloud into a targeted quantum state is provided, the apparatus comprising: an atom source for releasing a cloud of atoms to be driven into a targeted quantum state; a laser system configured to generate a laser beam to be directed onto the atom cloud in use, the laser beam having a frequency corresponding to a resonant frequency of an atomic transition for exciting the atoms into the targeted quantum state; a modulator configured to, in use, modulate the frequency of the laser beam responsive to an input signal; a waveform generator coupled to the modulator and configured to, in use, generate an input signal for the modulator, wherein the input signal is arranged to cause the modulator to modulate the laser light to generate a comb of frequencies around the resonant frequency of the atomic transition, the frequency comb including a plurality of peaks, each peak being separated by a frequency spacing, δω, that is determined based on a Rabi frequency, Ω, of the atomic transition to drive atoms of the atom cloud into a targeted quantum state.
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公开(公告)号：US11953580B2
公开(公告)日：2024-04-09
申请号：US17255281
申请日：2019-06-28
发明人： Paul Cannon , Matthew Angling
CPC分类号： G01S13/0218 , G01S7/40 , G01S13/003 , G01S13/917 , G01S2013/0227
摘要： A method for implementing a relocatable Over-The-Horizon-Radar (OTHR) including transmitting mutually orthogonal signals on each of a plurality of antenna elements of a transmitting system, and receiving and decoding the signals at a plurality of receiving systems to synthesize beams from the orthogonal signals. Each receiving system has a plurality of antenna elements fewer in number than the plurality of antenna elements of said transmitting system. The method includes connecting as a network the transmitting system, the plurality of receiving systems, and a network controller.
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公开(公告)号：US11890578B2
公开(公告)日：2024-02-06
申请号：US17270227
申请日：2019-05-01
发明人： Philip Andrew Davies
IPC分类号： B01D61/12 , B01D61/02 , B01D61/06 , B01D61/08 , C02F1/00 , C02F1/44 , F16K17/04 , F16K17/30 , C02F103/08
CPC分类号： B01D61/12 , B01D61/025 , B01D61/06 , B01D61/08 , C02F1/008 , C02F1/441 , F16K17/04 , F16K17/30 , B01D2311/14 , B01D2313/18 , B01D2313/243 , B01D2313/246 , B01D2315/10 , C02F2103/08 , C02F2201/005 , C02F2209/03 , C02F2303/10
摘要： A desalination system including: a partitioned container having upstream and downstream compartments divided by a movable partition, a first inlet port at an upstream end, and a second inlet port and an outlet port at the downstream end; a membrane container housing a cross-flow semipermeable membrane dividing the membrane container into saline and desalinated compartments, the saline compartment including first and second cross-flow ports, the desalinated compartment including a desalinated water outlet port; a feed pump connected to the first inlet port; a recharge pump having an inlet connected to the second cross-flow port and an outlet connected to the second inlet port; a main valve connected between the outlet port and the first cross-flow port; a bypass valve connecting the inlet port to the second cross-flow port and the recharge pump inlet; and a purge valve connecting the first cross-flow port and the main valve to a purge port.
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公开(公告)号：US20230408508A1
公开(公告)日：2023-12-21
申请号：US18035124
申请日：2021-11-04
发明人： Melissa GRANT , Tim ALBRECHT , Oliver IRVING
IPC分类号： G01N33/543 , B01L3/02
CPC分类号： G01N33/5438 , B01L3/022 , G01N2800/18 , B01L2400/0406 , B01L2300/0645 , B01L2300/0838
摘要： The present invention relates to a system and a device for use in the diagnosis of an oral disease. Methods, kits and compositions for use in the diagnosis of oral disease are also provided. More particularly, the invention relates to a system comprising a probe which is configured to collect a fluid sample from the oral cavity of a subject, and a detector which is configured to detect in the fluid sample the presence and/or concentration of an analyte which is indicative of the oral disease.
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公开(公告)号：US20230390283A1
公开(公告)日：2023-12-07
申请号：US18032994
申请日：2021-10-15
发明人： Zubair Ahmed , Richard Ian Tuxworth
IPC分类号： A61K31/497 , A61P25/28
CPC分类号： A61K31/497 , A61P25/28
摘要： The present disclosure relates to the treatment of neurological conditions, by inhibiting Chk2 kinase. Particular neurological conditions may be associated with neuronal damage/dysfunction or neurological degeneration, which may result from, physical trauma, chemical means, infection, inflammation, hypoxia and/or interruption in blood supply, or be due to a neurodegenerative disorder and/or autoimmune disease. The Chk2 inhibitor may be a small molecule, protein, peptide or nucleic acid. Exemplary small molecule Chk2 inhibitors include PV1019, AZD7762, CCT241533, BML-277 or prexasertib.
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公开(公告)号：US20230288183A1
公开(公告)日：2023-09-14
申请号：US18019573
申请日：2021-07-19
发明人： Kai BONGS , Michael HOLYNSKI , Rustin NOURSHARGH
IPC分类号： G01B9/02002 , G02F1/03 , G02F1/21 , G01B9/02001
CPC分类号： G01B9/02005 , G02F1/0327 , G02F1/217 , G01B9/02014 , G01C19/62
摘要： The application discloses an atom interferometer comprising an optical cavity and method of operation thereof. The atom interferometer includes a vacuum chamber, an optical cavity, a source for providing a cloud of atoms in the optical cavity in use, and one or more light sources. The one or more light sources are for generating, in the cavity, in use a first light beam having a first polarisation and at a first frequency for a two-photon interaction in the atoms; and a counterpropagating second light beam having a second polarisation orthogonal to the first polarisation and at a second frequency for the two-photon interaction in the atoms. The atom interferometer also includes an electro-optic element arranged in the cavity to be operable to simultaneously change: the resonant frequency of the cavity for light in the first polarisation to track changes in the frequency of the first light beam to compensate for the doppler shift of the falling atoms in use; and the resonant frequency of the cavity for light in the second polarisation to track changes in frequency of the counterpropagating second light beam to compensate for the doppler shift of the falling atoms in use.
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公开(公告)号：US20230218519A1
公开(公告)日：2023-07-13
申请号：US18009144
申请日：2021-06-11
IPC分类号： A61K9/06 , A61K47/10 , A61K47/42 , A61K47/02 , A61K47/36 , A61K47/08 , A61K38/17 , A61K31/573 , A61K31/7036 , A61K9/00 , A61K38/48
CPC分类号： A61K9/06 , A61K47/10 , A61K47/42 , A61K47/02 , A61K47/36 , A61K47/08 , A61K38/1709 , A61K31/573 , A61K31/7036 , A61K9/0048 , A61K38/482
摘要： Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.
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公开(公告)号：US20220389501A1
公开(公告)日：2022-12-08
申请号：US17761785
申请日：2020-09-18
IPC分类号： C12Q1/6869 , C12Q1/6806
摘要： The present invention relates to a method for analyzing DNA including forming labeled DNA fragments by cleaving genomic DNA into DNA fragments, selectively functionalizing any non-methylated CpG sites present in the DNA with a linker including a hydrolyzable moiety, and attaching a label to the linker. The method further includes the step of separating the labeled DNA fragments from any non-labeled DNA fragments, hydrolyzing the hydrolyzable moiety of the linker of the separated labeled DNA fragments so as to release the DNA fragments from the label, and sequencing the released DNA fragments.
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公开(公告)号：US20220340946A1
公开(公告)日：2022-10-27
申请号：US17761817
申请日：2020-09-18
IPC分类号： C12P19/34
摘要： A method of reversibly labeling a biomolecule including providing a linker molecule (11) having a first functional group (LG) with a reactive center, a second functional group (FG) with a reactive center, and a cleavable, e.g. hydrolyzable, moiety (A-B-C). The method further includes forming a covalent bond between the biomolecule (10) and the reactive center of the first functional group (LG), forming a covalent bond between a first label (L1) and the reactive center of the second functional group (FG), cleaving the cleavable moiety (A-B-C), e.g. hydrolyzing the hydrolyzable moiety, of the linker molecule (11) to remove the first label (L1) and to form a third functional group (W) with a reactive center, and forming a covalent bond between a further molecule and the reactive center of the third functional group (W) to reform the cleavable moiety, e.g. hydrolyzable moiety (A-B-C).
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